I think with dogs you would not make same combination again.
Dogs have mostly more than one pup in the litter.
So also you can see if more pups have the problem.
You can check the pedigree to see if there were more problems in the lines and after you make a second combination and there are pups again with epi it would be usefull to stop breeding with the mother.. same with the father if he had given epi before too.
If you have a female wich littermate had epi and she gets a pup with epi too i would stop breeding her.
But with people it is different.
you get 1 child. so for sure most people would try again.
I think if i were the parents i will not try to get a 3th child if the 2th also gets epi.
But to come back on the kiling of the pups.....
The parents are giving it... the problems. will you exeute the parents too after they gave a few pups with kinky tales etc etc
Or castrate?
If it is the parents there give it genetic to the pups,
lets call theme X liter.
And then you get a pup called X,Y from X liter there look god and have no erors.
You kill the brother to that puppy called X,O and the sister called X,P from X liter (because off ilnes or looks).
You sell puppy X,Y and when it become adult the new owner make puppys on X,Y.
What is there to prevent that X,Y gets puppys as X,O and X,P like the previus litter?
So what is the idea in killing X,O or X,P?
just dont get it.
then it would not help to kill that puppys brother or sister in the first place?